GENETIC DEFICIENCY OF GLYCOGEN SYNTHASE KINASE-3BETA CORRECTS DIABETES IN MOUSE MODELS OF INSULIN RESISTANCE.

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Despite treatment with agents that enhance beta-cell function and insulin action, reduction in beta-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus.Insulin resistance is characterized by impaired signaling through the insulin/insulin receptor/insulin receptor substrate/PI-3K/Akt pathway, leading to elevation

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Searching Explanations of Nature in the Mirror World of Math

Despite the huge scientific progress of the last century, the dynamics of complex systems such as the atmosphere, human societies, and ecosystems remain difficult to understand FABRIC SOFTENER and predict.Nonetheless, our ability to carve the future depends largely on our insight into the functioning of such complex systems.Complex systems are the

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Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry

The presence of antimicrobial resistance and virulence factors of 174 Escherichia coli strains isolated from healthy Portuguese Gallus gallus was evaluated.Resistance profiles were determined against 33 antimicrobials by microbroth dilution.Resistance was prevalent for tetracycline (70%) and ampicillin (63%).Extended-spectrum beta-lactamase (ESBL)

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